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Holiday Inn Express and Suites St.Louis South-I-55 — exterior view
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4-star property · ST. LOUIS

Holiday Inn Express and Suites St.Louis South-I-55

4250 Midamerica Lane, ST. LOUIS

4 star rating 4-star
About this hotel

Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis's newest and most modern Holiday Inn Express hotel is nestled within a growing development at the intersection of Butler Hill Road and I-55, just one mile south of I-270/255, with access to everything St. Louis offers. Located just 14 miles south of downtown St. Louis at exit 195 off I-55, business travelers will benefit from our ce…

Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis's newest and most modern Holiday Inn Express hotel is nestled within a growing development at the intersection of Butler Hill Road and I-55, just one mile south of I-270/255, with access to everything St. Louis offers. Located just 14 miles south of downtown St. Louis at exit 195 off I-55, business travelers will benefit from our central location with easy on/off access to I-55, connecting to different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center and Mercy Health. We are also minutes from MetLife, Anheuser-Busch, Cigna, and the National Cemetery Administration. Our non-smoking Holiday Inn Express & Suites St. Louis I-55 hotel offers convenient access for guests visiting Busch Stadium, the Gateway Arch, Grant's Farm, the Magic House, the St. Louis Science Center, the St. Louis Zoo, Forest Park, River City Casino, and much more! Hotel guests can enjoy an array of amenities, including suites, an indoor pool, a Suite Shop, two meeting rooms, a complimentary Express Start breakfast, complimentary high-speed wired and wireless internet, a comfortable Great Room with an outdoor patio, and warm cookies and milk served nightly. Experience genuine Midwestern hospitality at our South St. Louis location.

Your stay
Check-in
29 Aug 2026
Check-out
01 Sep 2026
Guests
2A · 0C · 1R
3 nights
Location

4250 Midamerica Lane, ST. LOUIS

Good to know
Payment at the hotel

When you book through Green Apple, you pay in AED via Paymob — Visa, Mastercard, Amex, Apple Pay, 3DS-secure.

Why book through Green Apple
Same hotel · better price

Net rates negotiated directly with Hotelbeds — often lower than the property's own site, always all-in.

Real humans on WhatsApp

Mid-trip change? Late arrival? Message +971 4 284 6712 — a person replies.

Established 2012

A DTCM-licensed Dubai travel house. IATA TIDS registered. 13+ years of arranging stays.

Guests also considered
Frequently asked

What are the check-in and check-out times at Holiday Inn Express and Suites St.Louis South-I-55?

Most properties check guests in from around 14:00 and check out by around 12:00 — the exact times are set by the hotel and appear on your voucher. Early check-in or late check-out can be requested, subject to availability — message our concierge on WhatsApp and we'll arrange it where the property allows.

Can I cancel my booking at Holiday Inn Express and Suites St.Louis South-I-55?

Cancellation policy is set per rate. Each rate card in the booking widget shows whether it is refundable and the exact deadline. Free-cancellation rates can be cancelled in seconds from your confirmation email. Non-refundable rates are clearly flagged before payment.

Is breakfast included?

Some rates include breakfast and others don't. The board basis (Room Only / Bed & Breakfast / Half Board / Full Board / All Inclusive) is shown on every rate card, so the choice is yours.

Why book through Green Apple Travel?

Green Apple is a Dubai-rooted travel house, established 2012 and IATA TIDS registered. We negotiate net rates directly with global suppliers (Hotelbeds) so you book the same hotel — often at a lower all-in price — and you get a real human on WhatsApp if anything changes mid-trip.
Need a hand?

Talk to a Dubai-based concierge.

Not sure on dates, room type, or rate? A real person replies on WhatsApp — same-day, in English, Arabic, or Russian.

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